Multiple people are dead and at least 50 are injured after an Amtrak train hit a dump truck at a crossing and derailed in Missouri on Monday, Chariton County Ambulance Service head Eric McKenzie told CNN.

Train 4 was carrying around 243 passengers and 12 crew members from Los Angelos to Chicago, but the train’s eight cars and two locomotives derailed after hitting the truck in Mendon shortly after 1:30 pm, Amtrak stated in a press release.

Videos from local outlet KAKE show passengers climbing out of the overturned train.